Endocrine Abstracts

Aminobisphosphonates impair osteoclast cell function and reduce bone remodelling rate. It has been speculated that atypical femoral fractures in patients on bisphosphonates are the result of impaired bone remodelling.The primary aim of this prospective study was to assess levels of bone remodelling in patients with osteoporosis on aminobisphosphonate therapy by measurement of bone turnover markers. The secondary aim was to assess the adequacy of concomit...

In contrast to bone formation biomarkers, reliable bone resorption biomarkers have not been available in serum. Recently, automated measurement of C-terminal cross-linking telopeptide of type I collagen (CTX-I), has been promoted as a reliable indicator of bone resorption. The objective of the study was to examine the correlation of CTX-I, with the traditional urinary markers, N-telopeptide of type I collagen (NTX-I) and deoxypyridinoline (DPD) in a series of patients with Pag...

Measurement of the various available bone formation and resorption markers provide insights into different aspects of the bone metabolism process. Interpretation of bone biomarkers in a clinical setting is complex. Analysis of formation markers including bone alkaline phosphatase, procollagen type 1 propeptide and intact osteocalcin and resorption markers including free deoxypyridinoline and N-terminal cross-linking telopeptide of type 1 collagen were performed. From the inter...

IntroductionLow Bone Mineral Density (BMD) is highly prevalent in adults with cystic fibrosis (CF) and is associated with increased fracture rates. We sought to establish how BMD changes with time in adults with CF and to determine what factors influence this change.MethodsA retrospective analysis of interval bone densitometry using Dual Energy X-ray Absorptiometry (DXA) scanning in 86 adults with CF was unde...

Background: Osteogenesis imperfecta is a group of heterogenous disorders affecting connective tissue. The disorders are inherited by autosomal dominant or recessive patterns. The phenotypes vary both between and within the subgroups of which there are eight described by the modified Sillence criteria. The common features are reduced bone mineralization, predisposition to fracture and resulting bony deformities. In addition blue sclerae and joint hyperlaxity can be present....

High levels of physical inactivity contribute to the development of obesity. We aimed to evaluate the benefits of exercise instruction in obese patients with type 2 diabetes who have demonstrated difficulty with weight management since diagnosis. Ethical approval was obtained from the local committee.Sixty-six patients were recruited from the diabetes out-patient clinics. All patients underwent treadmill-testing prior to randomisation. Patients were matc...

This study was designed to evaluate whether weight change in type 2 diabetes leads to deteriorating glycaemic control necessitating treatment escalation, or whether deteriorating glycaemic control results in medication change and possible weight gain.We studied 702 type 2 diabetic subjects with a follow-up of 56 plus/minus 2 months (mean plus/minus S.E.) treated on diet, metformin or sulphonylurea, alone or in combination. Patients who remained on diet alone (40 plus/minus...

The Diabetes Control and Complications Study, United States, and the United Kingdom Prospective Diabetes Study both reported increasing weight gain in all groups of patients with diabetes. The present study was designed to examine retrospectively if this was the experience in a clinic with an emphasis on weight loss as a central component of the treatment offered, facilitated by frequent clinic visits, the attendance of a dietitian at all clinics, a relatively low rate of insu...

Macroprolactin, a high molecular mass complex of prolactin and an IgG antibody is confined to the vasculature and exhibits limited bioactivity in vivo. Using a panel of sera obtained from 10 subjects whose hyperprolactinaemia was due entirely to macroprolactin this study aims to compare the level of detection of macroprolactin by 9 of the most commonly used prolactin immunoassays.The study involved 24 clinical laboratories employing the following 9 anal...

We aimed to establish the extent of adult cystic fibrosis-related diabetes (CFRD) in Ireland, and examine the differences between patients with CFRD and those with normal glucose handling.We conducted a retrospective analysis of patients with cystic fibrosis (CF) who attend the national referral centre for adult CF. Data including lung spirometry, sputum microbiology, bone mineral density and genotype were collected. Patients were diagnosed as having CFR...